Affordable Access

Access to the full text

Hepatic sclerosing hemangioma mimics hepatic malignancies: a case report and multidisciplinary approach

  • Sweed, Dina M.1
  • Fayed, Zeinab A.1
  • Sweed, Enas M.2
  • El-Sherif, Ahmed3
  • Mohamady, Mohamed1
  • 1 Menoufia University, Pathology Department, National Liver Institute, Al Menoufia, Egypt , Al Menoufia (Egypt)
  • 2 Benha University, Radiology Department, Faculty of Medicine, Benha, Egypt , Benha (Egypt)
  • 3 Menoufia University, Hepato-pancreatobiliary Surgery and Liver Transplantation, National Liver Institute, Al Menoufia, Egypt , Al Menoufia (Egypt)
Published Article
Egyptian Liver Journal
Springer Berlin Heidelberg
Publication Date
Nov 14, 2019
DOI: 10.1186/s43066-019-0007-6
Springer Nature


BackgroundHepatic sclerosing hemangiomas (HSH) are rare benign vascular tumors that mimic radiologically hepatic malignancies. HSH is characterized by extensive fibrosis and hyalinosis as a result of degeneration and thrombosis. Pre-operative diagnosis is very difficult and most of the cases undergo surgical resections.Case presentationA 65 years old, hepatitis C virus-infected female presented by an accidentally discovered hepatic focal lesion. Magnetic resonance imaging (MRI) showed a T2 hyperintense mass displaying peripheral enhancement in porto-venous phase. The patient had a simultaneous typical hepatic hemangioma and multiple vertebral bodies’ hemangiomata. Tissue-guided biopsy revealed a densely sclerotic stroma containing vascular spaces with occasional obliteration of the lumen. Immunohistochemical staining was performed for Pan CK, CD34, SMA, VEGF, and c-Kit which confirmed the vascular nature of neoplasm and the involuting phase of hemangioma development. The patient was reassured and recommended for a regular radiological follow-up to reassess the lesion size.ConclusionThe definitive preoperative diagnosis of HSH is still problematic. However, the awareness of surgeons by this entity, peripheral enhancement in porto-venous phase on dynamic MRI, the presence of simultaneous typical hepatic hemangioma in the absence of cancer history could raise suspicion for HSH. Liver biopsy is still the gold standard in approaching the accurate diagnosis.

Report this publication


Seen <100 times