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Hepatic pathology in vitamin A toxicity.

Authors
  • Forouhar, F
  • Nadel, M S
  • Gondos, B
Type
Published Article
Journal
Annals of clinical and laboratory science
Publication Date
Jan 01, 1984
Volume
14
Issue
4
Pages
304–310
Identifiers
PMID: 6465834
Source
Medline
License
Unknown

Abstract

This paper documents a case of vitamin A toxicity presenting with splenomegaly and ascites. The light microscopic, electron microscopic, and fluorescent findings are described in detail. The principal histopathologic finding was marked perisinusoidal fibrosis. The role of Ito cells in the storage of lipid-soluble vitamins and their subsequent transformation to fibroblasts producing collagen are discussed.

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