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Hepatic alanine-glyoxylate aminotransferase activity and oxalate metabolism in vitamin B6 deficient rats.

Authors
  • Nishijima, Saori
  • Sugaya, Kimio
  • Morozumi, Makoto
  • Hatano, Tadashi
  • Ogawa, Yoshihide
Type
Published Article
Journal
The Journal of Urology
Publisher
Elsevier
Publication Date
Feb 01, 2003
Volume
169
Issue
2
Pages
683–686
Identifiers
PMID: 12544342
Source
Medline
License
Unknown

Abstract

Vitamin B6 deficiency not only decreased alanine-glyoxylate aminotransferase activity, but also down-regulated alanine-glyoxylate aminotransferase gene expression by hepatocytes and led to hyperoxaluria and hyperglycolic aciduria secondary to impaired metabolism of oxalate precursors. Hyperoxaluria with hypocitruria may also contribute to calcium oxalate stone formation in vitamin B6 deficiency.

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