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Heparin assisted photochemical synthesis of gold nanoparticles and their performance as SERS substrates.

Authors
  • Rodríguez-Torres, Maria del Pilar
  • Díaz-Torres, Luis Armando
  • Romero-Servin, Sergio
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Jan 01, 2014
Volume
15
Issue
10
Pages
19239–19252
Identifiers
DOI: 10.3390/ijms151019239
PMID: 25342319
Source
Medline
License
Unknown

Abstract

Reactive and pharmaceutical-grade heparins were used as biologically compatible reducing and stabilizing agents to photochemically synthesize colloidal gold nanoparticles. Aggregates and anisotropic shapes were obtained photochemically under UV black-light lamp irradiation (λ = 366 nm). Heparin-functionalized gold nanoparticles were characterized by Scanning Electron Microscopy and UV-Vis spectroscopy. The negatively charged colloids were used for the Surface Enhanced Raman Spectroscopy (SERS) analysis of differently charged analytes (dyes). Measurements of pH were taken to inspect how the acidity of the medium affects the colloid-analyte interaction. SERS spectra were taken by mixing the dyes and the colloidal solutions without further functionalization or addition of any aggregating agent.

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