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Henoch-Schönlein purpura in a renal transplant recipient with prior IgA nephropathy following influenza vaccination.

Authors
  • McNally, Andrew1
  • McGregor, David1
  • Searle, Martin1
  • Irvine, John1
  • Cross, Nicholas1
  • 1 Department of Nephrology , Christchurch Hospital, Canterbury District Health Board , Christchurch , New Zealand. , (New Zealand)
Type
Published Article
Journal
Clinical kidney journal
Publication Date
Jun 01, 2013
Volume
6
Issue
3
Pages
313–315
Identifiers
DOI: 10.1093/ckj/sft029
PMID: 26064492
Source
Medline
Keywords
License
Unknown

Abstract

Henoch-Schönlein purpura (HSP) is a systemic small-vessel leucocytoclastic vasculitis with deposition of immune complexes containing Immunoglobulin A (IgA). IgA Nephropathy (IgAN) is a glomerulonephritis caused by mesangial deposition of IgA. The onset of HSP, but not IgAN, has been linked to influenza vaccination. We report the first case of HSP with glomerular involvement, in a renal transplant recipient following influenza vaccination. The patient had prior end-stage renal failure (ESRF) secondary to IgAN, without clinical evidence of IgAN recurrence after transplantation. This is of clinical relevance as influenza vaccination is regarded safe, effective, and recommended after renal transplantation. Nephrologists should be aware of the potential for influenza vaccination to have adverse effects in renal transplant recipients, especially if the primary renal disease is HSP or IgAN.

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