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[Hemolytic disease of neonates due to anti-M: report of one case and review of reports of 21 cases].

Authors
  • Gao, Xiang-yu
  • Huang, Huan
  • Li, Li-da
Type
Published Article
Journal
Zhonghua er ke za zhi. Chinese journal of pediatrics
Publication Date
Sep 01, 2009
Volume
47
Issue
9
Pages
648–652
Identifiers
PMID: 20021783
Source
Medline
License
Unknown

Abstract

HDN of varying degrees of severity has been reported in association with anti-M and can even lead to intrauterine deaths or requiring treatment with exchange transfusion. If the mother has a history of prior intrauterine deaths, abortion, hydrops fetalis, severe fetal anemia or infertile, MN blood group and anti-M antibodies should be tested after excluding the possibility of other causes and HDN due to ABO or Rh blood group incompatibility. As the efficacy of phototherapy increases, the role of exchange transfusion in acute management is rapidly decreasing. High-dose intravenous immunoglobulin and/or intramuscular metalloporphyrins may further reduce the need for exchange transfusion. The exchange transfusion may be performed through peripheral arterial (drawn out) and venous (infused in) lines.

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