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Hemolysis in patients with antibody deficiencies on immunoglobulin replacement treatment.

Authors
  • Quinti, Isabella
  • Pulvirenti, Federica
  • Milito, Cinzia
  • Granata, Guido
  • Giovannetti, Gianluca
  • La Marra, Fabiola
  • Pesce, Anna M
  • Farrugia, Albert
  • Coluzzi, Serelina
  • Girelli, Gabriella
Type
Published Article
Journal
Transfusion
Publication Date
May 01, 2015
Volume
55
Issue
5
Pages
1067–1074
Identifiers
DOI: 10.1111/trf.12939
PMID: 25532440
Source
Medline
License
Unknown

Abstract

Hemolysis occurred in patients receiving immunoglobulin at replacement dosages. Polyvalent immunoglobulin preparations contained multiple clinically significant antibodies that could have unexpected hemolytic consequences, as anti-C whose research and titration are not required by the European Pharmacopoeia. The issue of hemolysis in long-term recipients of immunoglobulin treatment administered at replacement dosages should be more widely recognized.

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