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Hemoglobinopathic erythrocytes affect the intraerythrocytic multiplication of Plasmodium falciparum in vitro.

Authors
  • Glushakova, Svetlana1
  • Balaban, Amanda1
  • McQueen, Philip G2
  • Coutinho, Rosane3
  • Miller, Jeffery L4
  • Nossal, Ralph1
  • Fairhurst, Rick M5
  • Zimmerberg, Joshua1
  • 1 Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health.
  • 2 Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health.
  • 3 Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health.
  • 4 Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.
  • 5 Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Type
Published Article
Journal
The Journal of Infectious Diseases
Publisher
Oxford University Press
Publication Date
Oct 01, 2014
Volume
210
Issue
7
Pages
1100–1109
Identifiers
DOI: 10.1093/infdis/jiu203
PMID: 24688070
Source
Medline
Keywords
License
Unknown

Abstract

P. falciparum IMF, a parasite heritable virulence trait, correlates with erythrocyte indices and is reduced in thalassemia trait erythrocytes. Parasite IMF should be examined in other low-indices erythrocytes.

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