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Hemoglobinopathic erythrocytes affect the intraerythrocytic multiplication of Plasmodium falciparum in vitro.

Authors
  • 1
  • 1
  • 2
  • 3
  • 4
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  • 1 Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health.
  • 2 Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health.
  • 3 Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health.
  • 4 Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.
  • 5 Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Type
Published Article
Journal
The Journal of Infectious Diseases
1537-6613
Publisher
Oxford University Press
Publication Date
Volume
210
Issue
7
Pages
1100–1109
Identifiers
DOI: 10.1093/infdis/jiu203
PMID: 24688070
Source
Medline
Keywords
License
Unknown

Abstract

P. falciparum IMF, a parasite heritable virulence trait, correlates with erythrocyte indices and is reduced in thalassemia trait erythrocytes. Parasite IMF should be examined in other low-indices erythrocytes.

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