A hemodynamic measurement system incorporating echocardiography with Doppler, the Evans-Blue method, and sphygmomanometry enables the clinician to estimate cardiac output, blood volume, cardiac contractile force, and total peripheral resistance. These determinations can be used by the clinician to choose appropriate antihypertensive therapy without resorting to the usual trial-and-error approach. With the aid of hemodynamic measurements, the treatment of hypertension can evolve from merely lowering blood pressure to correcting the whole hemodynamic derangement. In this study, the accuracies and normal ranges of the measurements were critically examined. Results of a comparative trial showed that use of hemodynamic measurements decreased the incidence of side effects and improved compliance of patients to the prescribed antihypertensive regimen.