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Hemodynamic effects of di-sec-butyl phenol, an anesthetic substituted phenol.

Authors
  • Ya Deau, Jacques T1
  • Heerdt, Paul M
  • The, Andrew H S
  • Wang, Qingwen
  • 1 Hospital for Special Surgery, Weill Medical College, Cornell University, New York, NY 10021, USA. [email protected]
Type
Published Article
Journal
Pharmacology
Publication Date
Jan 01, 2006
Volume
76
Issue
3
Pages
117–122
Identifiers
PMID: 16374073
Source
Medline
License
Unknown

Abstract

Dose- and age-related hemodynamic effects were determined for an anesthetic substituted phenol, 2,6-di-sec-butyl phenol (DSB). DSB, 7.5 mg/kg, induced hypnosis in young rabbits and increased mean blood pressure to 170 +/- 14% and heart rate to 150 +/- 21% of control values. In elderly rabbits, 7.5 mg/kg DSB induced hypnosis, had no effect on blood pressure, but increased the heart rate to 130 +/- 2% of control. After ganglionic blockade with hexamethonium, 7.5 mg/kg DSB caused a decline in mean blood pressure (71 +/- 5% of control) without change in heart rate. DSB increased norepinephrine release from SH-SY5Y cells, a human neuroblastoma cell line (5.4 +/- 1.7% vs. 3.5 +/- 0.3%). DSB produced age-dependent elevation of mean blood pressure in rabbits, probably by causing release of catecholamines from the sympathetic nervous system.

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