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Hemodynamic changes induced by prolonged NaCl and DOCA administration in spontaneously hypertensive rats.

Authors
  • Chrysant, S G
  • Walsh, G M
  • Frohlich, E D
  • Townsend, S M
Type
Published Article
Journal
Angiology
Publication Date
Apr 01, 1978
Volume
29
Issue
4
Pages
303–309
Identifiers
PMID: 655461
Source
Medline
License
Unknown

Abstract

The results of this study demonstrate that the spontaneously hypertensive rat is sensitive to salt excess. The hypertensinogenic effect of salt was mediated through elevation of peripheral vascular resistance. The addition of DOCA aggravated the hypertension, mainly be elevating the cardiac output without appreciably decreasing peripheral vascular resistance. SHR'S EXPOSED TO 1% NaCl consumed more fluids and excreted more sodium and urine than control rats. Those exposed to 1% NaCl and DOCA had higher fluid consumptions and excreted more sodium than the other two groups. These effects of sodium in a neurogenic strain of hypertensive rats suggest a possible interplay between the neurogenic and salt-dependent components in the development and maintenance of hypertension. They also suggest that SHRs, like other hypertensive rat models, are salt sensitive.

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