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Hemocompatibility evaluation of DLC-and SiC- coated surfaces

Authors
  • Nurdin, N.
  • François, P.
  • Mugnier, Yannick
  • Krumeich, J.
  • Moret, M.
  • Aransson, B.O.
  • Descouts, P.
Publication Date
Jan 01, 2003
Source
HAL
Keywords
Language
English
License
Unknown
External links

Abstract

Diamond-like carbon (DLC) and silicon carbide (SiC) coat- ings are attractive because of low friction coefficient, high hardness, chemical inertness and smooth finish, which they provide to biomedical devices. Silicon wafers (Si and silicone rubber (Si) plates were coated using plasma- enhanced chemical vapour deposition (PE-CVD) tech- niques. This article describes: 1- the characterization of modified surfaces using attenuated total reflection-Fourier transform infrared spectroscopy (ATR/FTIR) and contact angle measurements, 2- the results of three in-vitro haemocompatibility assays. Coated surfaces were compared to uncoated materials and various substrates such as polymethylmethacrylate (PMMA), polyethylene (LDPE), polydimethylsiloxane (PDMS) and medical steel (MS). Thrombin generation, blood platelet adhesion and com- plement convertase activity tests revealed the following classification, from the most to the least heamocompatible

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