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Hemimegalencephaly: 2D, 3D Ultrasound and MRI Correlation

Authors
  • Romero, X.C.
  • Molina, F.S.
  • Pastor, E.
  • Amaya, F.
Type
Published Article
Journal
Fetal Diagnosis and Therapy
Publisher
S. Karger AG
Publication Date
Nov 27, 2010
Volume
29
Issue
3
Pages
257–260
Identifiers
DOI: 10.1159/000322012
PMID: 21109730
Source
Karger
Keywords
License
Green
External links

Abstract

Background: Hemimegalencephaly (HMC) is a disorder associated with enlarged and dysplastic hamartomatous overgrowth of all or part of the one cerebral hemisphere that can be isolated or associated with other syndromes. In the normal development of the brain it is important to bear in mind that there are two main processes: firstly the development of the hemispheres and the corpus callosum, and secondly the cortical formation with proliferation, migration and organization of the cortex, which occurs mostly between 12 and 20 weeks of gestation. Case Report: We present a 22-week-old fetus with macrocephaly depending on HMC and emphasize the possibility of an early ultrasound diagnosis, the correlation in the diagnosis between 2D and 3D ultrasound, and the use of magnetic resonance imaging as an imaging method for a more precise diagnosis of neuronal migration anomalies. Conclusion: The diagnosis of HMC is possible at the time of the anomaly scan. The use and correlation with other diagnostic tools provide essential information for parent counseling in these complex cases.

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