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Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review.

Authors
Type
Published Article
Journal
World Journal of Gastroenterology
1007-9327
Publisher
Baishideng Publishing Group Co
Publication Date
Volume
19
Issue
23
Pages
3555–3561
Identifiers
DOI: 10.3748/wjg.v19.i23.3555
PMID: 23801856
Source
Medline
Keywords
License
Unknown

Abstract

Ischemia/reperfusion (I/R) injury of the gut is a significant problem in a variety of clinical settings and is associated with a high morbidity and mortality. Although the mechanisms involved in the pathogenesis of gut I/R injury have not been fully elucidated, it is generally believed that oxidative stress with subsequent inflammatory injury plays an important role. Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, followed by production of CO, biliverdin, and free iron. The HO system is believed to confer cytoprotection by inhibiting inflammation, oxidation, and apoptosis, and maintaining microcirculation. HO-1, an inducible form of HO, serves a vital metabolic function as the rate-limiting step in the heme degradation pathway, and affords protection in models of intestinal I/R injury. HO-1 system is an important player in intestinal I/R injury condition, and may offer new targets for the management of this condition.

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