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The hematopoietic niche: a Drosophila model, at last.

Authors
Type
Published Article
Journal
Cell Cycle
1551-4005
Publisher
Landes Bioscience
Publication Date
Volume
6
Issue
12
Pages
1443–1444
Identifiers
PMID: 17582220
Source
Medline
License
Unknown

Abstract

The niche provides a specialised microenvironment necessary for maintenance of stem cells in a non differentiated state. While the hematopoietic stem cell (HSC) niche in vertebrates was the first to be recognized, Drosophila niches supporting germline stem cells were characterised first. Recent evidence for the existence of a niche maintaining hematopoietic precursors in Drosophila opens the way to study in vivo the niche/hematopoietic precursors interactions. The availability of a large collection of cell markers, mutants and sophisticated genetic tools makes Drosophila an attractive model for investigating the cellular and molecular mechanisms that are involved in these interactions.

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