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Hematopoiesis and microenvironment in hematological malignancies.

Authors
  • Cheng, Hui1, 2, 3, 4
  • Sun, Guohuan1, 2
  • Cheng, Tao1, 2, 3, 4
  • 1 State Key Laboratory of Experimental Hematology, China. , (China)
  • 2 Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. , (China)
  • 3 Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin, China. , (China)
  • 4 Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin, China. , (China)
Type
Published Article
Journal
Cell regeneration (London, England)
Publication Date
Sep 01, 2018
Volume
7
Issue
1
Pages
22–26
Identifiers
DOI: 10.1016/j.cr.2018.08.002
PMID: 30671226
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Adult hematopoietic stem cells (HSCs) and progenitors (HPCs) reside in the bone marrow, a highly orchestrated architecture. In the bone marrow, the process of how HSCs exert self-renewal and differentiation is tightly regulated by the surrounding microenvironment, or niche. Recent advances in imaging technologies and numerous knockout or knockin mouse models have greatly improved our understanding of the organization of the bone marrow niche. This niche compartment includes a complex network of mesenchymal stem cells (MSC), osteolineage cells, endothelial cells (arterioles and sinusoids), sympathetic nerves, nonmyelinating Schwann cells and megakaryocytes. In addition, different types of mediators, such as cytokines/chemokines, reactive oxygen species (ROS) and exosomes play a pivotal role in regulating the function of hematopoietic cells. Therefore, the niche components and the hematopoietic system make up an ecological environment that maintains the homeostasis and responds to stress, damage or disease conditions. On the other hand, the niche compartment can become a traitor that can do harm to normal hematopoietic cells under pathological conditions. Studies on the diseased bone marrow niche have only recently begun to appear in the extant literature. In this short review, we discuss the most recent advances regarding the behaviors of normal hematopoietic cells and their niche alterations in hematological malignancies.

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