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Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females.

Authors
  • Pedrini, Marzena J Fabis
  • Seewann, Alexandra
  • Bennett, Kirsten A
  • Wood, Alex J T
  • James, Ian
  • Burton, Jason
  • Marshall, Barry J
  • Carroll, William M
  • Kermode, Allan G
Type
Published Article
Journal
Journal of Neurology Neurosurgery & Psychiatry
Publisher
BMJ
Publication Date
Jun 01, 2015
Volume
86
Issue
6
Pages
603–607
Identifiers
DOI: 10.1136/jnnp-2014-309495
PMID: 25602009
Source
Medline
Keywords
License
Unknown

Abstract

Our results could reflect a protective role of H. pylori in the disease development. However, it may be that H. pylori infection is a surrogate marker for the 'hygiene hypothesis', a theory which postulates that early life infections are essential to prime the immune system and thus prevent allergic and autoimmune conditions later in life. The fact that the association between H. pylori seropositivity and MS risk was seen almost exclusively in females requires further investigation.

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