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Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells.

Authors
  • Keates, Sarah
  • Keates, Andrew C
  • Katchar, Kianoosh
  • Peek, Richard M Jr
  • Kelly, Ciaran P
Type
Published Article
Journal
The Journal of infectious diseases
Publication Date
Jul 01, 2007
Volume
196
Issue
1
Pages
95–103
Identifiers
PMID: 17538889
Source
Medline
License
Unknown

Abstract

Infection of gastric epithelial cells by H. pylori triggers an autocrine loop whereby EGFR transactivation leads to the up-regulation of EGFR expression. This, in turn, may contribute to unrestrained epithelial cell proliferation and carcinogenesis.

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