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Hedgehog signaling pathway and lung cancer.

Authors
  • Velcheti, Vamsidhar
  • Govindan, Ramaswamy
Type
Published Article
Journal
Journal of Thoracic Oncology
Publisher
Elsevier
Publication Date
Jan 01, 2007
Volume
2
Issue
1
Pages
7–10
Identifiers
PMID: 17410003
Source
Medline
License
Unknown

Abstract

Signaling pathways responsible for embryogenesis play a critical role in the maintenance of stem cells in adult life and cellular responses to injury. Dysfunction of the developmental signaling pathways during adult homeostasis leads to various events resulting in the development of neoplasia. We review the biology of the hedgehog signaling pathway and its potential role in the development of lung cancer.

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