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Heat inactivation of the Middle East respiratory syndrome coronavirus.

Authors
  • Leclercq, India
  • Batéjat, Christophe
  • Burguière, Ana M
  • Manuguerra, Jean-Claude
Type
Published Article
Journal
Influenza and Other Respiratory Viruses
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 01, 2014
Volume
8
Issue
5
Pages
585–586
Identifiers
DOI: 10.1111/irv.12261
PMID: 25074677
Source
Medline
Keywords
License
Unknown

Abstract

The culture supernatants of the emerging Middle East respiratory syndrome coronavirus (MERS-CoV) were submitted to three temperatures over time and tested for infectivity by TCID50 method on Vero E6 cells. At 56°C, almost 25 minutes were necessary to reduce the initial titre by 4 log10 . Increasing temperature to 65°C had a strong negative effect on viral infectivity as virucidy dropped significantly to 1 minute. On the contrary, no significant decrease in titre was observed after 2 hours at 25°C. These data might be useful in establishing biosafety measures in laboratories against MERS-CoV.

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