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The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds

Authors
  • Bahraminasab, Marjan
  • Talebi, Athar
  • Doostmohammadi, Nesa
  • Arab, Samaneh
  • Ghanbari, Ali
  • Zarbakhsh, Sam
Type
Published Article
Journal
Journal of Orthopaedic Surgery and Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jun 20, 2022
Volume
17
Identifiers
DOI: 10.1186/s13018-022-03213-2
PMCID: PMC9208215
Source
PubMed Central
Keywords
Disciplines
  • Research
License
Unknown

Abstract

In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds.

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