Hb M Milwaukee: direct detection of the beta-globin gene mutation in three generations of an afflicted family.
- Published Article
- Publication Date
Jan 01, 1983
Chromosomal DNA from three individuals with familial hemoglobin M (Hb M) Milwaukee was studied by restriction endonuclease analysis. The segregation of the mutant beta-globin gene could be followed through three generations by direct Sst I analysis at the gene level. Various restriction endonucleases were used to confirm the positions of Sst I sites in the delta-beta A- and delta-beta Mi-globin gene regions.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6311728