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Hb M Milwaukee: direct detection of the beta-globin gene mutation in three generations of an afflicted family.

Authors
  • Oehme, R
  • Kohne, E
  • Kleihauer, E
  • Horst, J
Type
Published Article
Journal
Human genetics
Publication Date
Jan 01, 1983
Volume
64
Issue
4
Pages
376–379
Identifiers
PMID: 6311728
Source
Medline
License
Unknown

Abstract

Chromosomal DNA from three individuals with familial hemoglobin M (Hb M) Milwaukee was studied by restriction endonuclease analysis. The segregation of the mutant beta-globin gene could be followed through three generations by direct Sst I analysis at the gene level. Various restriction endonucleases were used to confirm the positions of Sst I sites in the delta-beta A- and delta-beta Mi-globin gene regions.

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