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Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy.

Authors
  • Coschi, Courtney H
  • Ishak, Charles A
  • Gallo, David
  • Marshall, Aren
  • Talluri, Srikanth
  • Wang, Jianxin
  • Cecchini, Matthew J
  • Martens, Alison L
  • Percy, Vanessa
  • Welch, Ian
  • Boutros, Paul C
  • Brown, Grant W
  • Dick, Frederick A
Type
Published Article
Journal
Cancer Discovery
Publisher
American Association for Cancer Research
Publication Date
Jul 01, 2014
Volume
4
Issue
7
Pages
840–853
Identifiers
DOI: 10.1158/2159-8290.CD-14-0215
PMID: 24740996
Source
Medline
License
Unknown

Abstract

Genome instability is inherent to most cancers and is the basis for selective killing of cancer cells by genotoxic therapeutics. In this report, we demonstrate that instability can be caused by loss of a single allele of the retinoblastoma gene that prevents proper replication and condensation of pericentromeric chromosomal regions, leading to elevated levels of aneuploidy in cancer.

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