Affordable Access

Halogenation and topical corticosteroids: a comparison between the 17-butyrate esters of hydrocortisone and clobetasone in ointment bases.

Authors
  • Allenby, C F
  • Sparkes, C G
Type
Published Article
Journal
The British journal of dermatology
Publication Date
Feb 01, 1981
Volume
104
Issue
2
Pages
179–183
Identifiers
PMID: 7011356
Source
Medline
License
Unknown

Abstract

Clobetasone butyrate 0.05% (Eumovate), a halogenated topical steroid, was compared with hydrocortison butyrate 0.1% (Locoid) which does not contain any halogen atoms. In the treatment of eczema there was not difference between the preparations, but in that of psoriasis the halogen-containing steriod was significantly more effective. Under normal circumstances neither preparation had any detectable effect on adrenal function, but with large doses under total-body polythene occlusion, circulating cortisol levels were reduced less by the halogenated than by the non-halogenated preparation. Corticosteroids which contain a halogen atom are often considered to cause more adverse effects than the non-halogenated preparations with similar clinical efficacy. This study shows that this cannot be assumed for their ability to suppress cortisol levels.

Report this publication

Statistics

Seen <100 times