Affordable Access

deepdyve-link
Publisher Website

Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria.

Authors
  • Nakamura, Fumiaki1
  • Kudo, Norio2
  • Tomachi, Yuki1
  • Nakata, Akiko2
  • Takemoto, Misao2
  • Ito, Akihiro3, 4
  • Tabei, Hodaka1
  • Arai, Daisuke5
  • de Voogd, Nicole6
  • Yoshida, Minoru2, 3, 7
  • Nakao, Yoichi1, 5
  • Fusetani, Nobuhiro5, 8
  • 1 Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan. , (Japan)
  • 2 Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, Saitama, Japan. , (Japan)
  • 3 Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan. , (Japan)
  • 4 School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan. , (Japan)
  • 5 Research Institute for Science and Engineering, Waseda University, Tokyo, Japan. , (Japan)
  • 6 Naturalis Biodiversity Center, Leiden, The Netherlands. , (Netherlands)
  • 7 Department of Biotechnology, Graduate School of Agricultural Life Sciences, The University of Tokyo, Tokyo, Japan. , (Japan)
  • 8 Fisheries and Oceans Hakodate, Hakodate, Japan. , (Japan)
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Feb 01, 2018
Volume
71
Issue
2
Pages
273–278
Identifiers
DOI: 10.1038/ja.2017.145
PMID: 29184120
Source
Medline
License
Unknown

Abstract

Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.

Report this publication

Statistics

Seen <100 times