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H2O2 generation by bacillus Calmette-Guérin induces the cellular oxidative stress response required for bacillus Calmette-Guérin direct effects on urothelial carcinoma biology.

Authors
  • Shah, Gopitkumar1
  • Zielonka, Jacek1
  • Chen, Fanghong1
  • Zhang, Guangjian1
  • Cao, YanLi1
  • Kalyanaraman, Balaraman1
  • See, William1
  • 1 Departments of Urology and Biophysics (JZ, BK), Medical College of Wisconsin, Milwaukee, Wisconsin.
Type
Published Article
Journal
The Journal of urology
Publication Date
October 2014
Volume
192
Issue
4
Pages
1238–1248
Identifiers
DOI: 10.1016/j.juro.2014.05.115
PMID: 24928267
Source
Medline
Keywords
License
Unknown

Abstract

This study demonstrates the importance of free radical generation by bacillus Calmette-Guérin and intracellular generation of cellular oxidative stress on the urothelial carcinoma cell response to the bacillus. Manipulating the cellular oxidative stress induced by bacillus Calmette-Guérin represents a potential target to increase the efficacy of the bacillus.

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