Affordable Access

Access to the full text

Gut-Derived Metabolites and Their Role in Immune Dysfunction in Chronic Kidney Disease

Authors
  • Glorieux, Griet
  • Gryp, Tessa
  • Perna, Alessandra
Type
Published Article
Journal
Toxins
Publisher
MDPI AG
Publication Date
Apr 11, 2020
Volume
12
Issue
4
Identifiers
DOI: 10.3390/toxins12040245
PMID: 32290429
PMCID: PMC7232434
Source
PubMed Central
Keywords
License
Green

Abstract

Several of the uremic toxins, which are difficult to remove by dialysis, originate from the gut bacterial metabolism. This opens opportunities for novel targets trying to decrease circulating levels of these toxins and their pathophysiological effects. The current review focuses on immunomodulatory effects of these toxins both at their side of origin and in the circulation. In the gut end products of the bacterial metabolism such as p-cresol, trimethylamine and H2S affect the intestinal barrier structure and function while in the circulation the related uremic toxins stimulate cells of the immune system. Both conditions contribute to the pro-inflammatory status of patients with chronic kidney disease (CKD). Generation and/or absorption of these toxin precursors could be targeted to decrease plasma levels of their respective uremic toxins and to reduce micro-inflammation in CKD.

Report this publication

Statistics

Seen <100 times