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The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study.

Authors
  • Wu, Hao1
  • Tremaroli, Valentina1
  • Schmidt, Caroline1
  • Lundqvist, Annika1
  • Olsson, Lisa M1
  • Krämer, Manuela1
  • Gummesson, Anders2
  • Perkins, Rosie1
  • Bergström, Göran3
  • Bäckhed, Fredrik4
  • 1 The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Bruna Stråket 16, 41345 Gothenburg, Sweden. , (Sweden)
  • 2 The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Bruna Stråket 16, 41345 Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Genetics and Genomics, Gothenburg, Sweden. , (Sweden)
  • 3 The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Bruna Stråket 16, 41345 Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Physiology, Gothenburg, Sweden. , (Sweden)
  • 4 The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Bruna Stråket 16, 41345 Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Physiology, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Science University of Copenhagen, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
Type
Published Article
Journal
Cell metabolism
Publication Date
Sep 01, 2020
Volume
32
Issue
3
Identifiers
DOI: 10.1016/j.cmet.2020.06.011
PMID: 32652044
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The link between the gut microbiota and type 2 diabetes (T2D) warrants further investigation because of known confounding effects from antidiabetic treatment. Here, we profiled the gut microbiota in a discovery (n = 1,011) and validation (n = 484) cohort comprising Swedish subjects naive for diabetes treatment and grouped by glycemic status. We observed that overall gut microbiota composition was altered in groups with impaired glucose tolerance, combined glucose intolerance and T2D, but not in those with impaired fasting glucose. In addition, the abundance of several butyrate producers and functional potential for butyrate production were decreased both in prediabetes and T2D groups. Multivariate analyses and machine learning microbiome models indicated that insulin resistance was strongly associated with microbial variations. Therefore, our study indicates that the gut microbiota represents an important modifiable factor to consider when developing precision medicine approaches for the prevention and/or delay of T2D. Copyright © 2020 Elsevier Inc. All rights reserved.

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