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The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.

Authors
  • Schuijt, Tim J1
  • Lankelma, Jacqueline M2
  • Scicluna, Brendon P2
  • de Sousa e Melo, Felipe2
  • Roelofs, Joris J T H3
  • de Boer, J Daan2
  • Hoogendijk, Arjan J2
  • de Beer, Regina2
  • de Vos, Alex2
  • Belzer, Clara4
  • de Vos, Willem M5
  • van der Poll, Tom6
  • Wiersinga, W Joost6
  • 1 Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Clinical Chemistry, Hematology and Immunology, Diakonessenhuis Utrecht, The Netherlands. , (Netherlands)
  • 2 Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. , (Netherlands)
  • 3 Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. , (Netherlands)
  • 4 Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands. , (Netherlands)
  • 5 Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands Department of Bacteriology & Immunology, Helsinki University, Helsinki, Finland. , (Finland)
  • 6 Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Gut
Publisher
BMJ
Publication Date
Apr 01, 2016
Volume
65
Issue
4
Pages
575–583
Identifiers
DOI: 10.1136/gutjnl-2015-309728
PMID: 26511795
Source
Medline
Keywords
License
Unknown

Abstract

This study identifies the intestinal microbiota as a protective mediator during pneumococcal pneumonia. The gut microbiota enhances primary alveolar macrophage function. Novel therapeutic strategies could exploit the gut-lung axis in bacterial infections.

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