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Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study.

Authors
  • Hacioglu, Aysa1
  • Gundogdu, Aycan2, 3
  • Nalbantoglu, Ufuk3, 4
  • Karaca, Zuleyha1
  • Urhan, Muhammed Emre1
  • Sahin, Serdar5
  • Dokmetas, Hatice Sebile6
  • Kadioglu, Pinar5
  • Kelestimur, Fahrettin7
  • 1 Department of Endocrinology, School of Medicine, Erciyes University, Kayseri, Turkey. , (Turkey)
  • 2 Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey. , (Turkey)
  • 3 Genome and Stem Cell Center (GenKok), Erciyes University, Kayseri, Turkey. , (Turkey)
  • 4 Department of Computer Engineering, Erciyes University, Kayseri, Turkey. , (Turkey)
  • 5 Department of Endocrinology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey. , (Turkey)
  • 6 Department of Endocrinology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey. , (Turkey)
  • 7 Department of Endocrinology, School of Medicine, Yeditepe University, Istanbul, Turkey. [email protected] , (Turkey)
Type
Published Article
Journal
Pituitary
Publisher
Springer-Verlag
Publication Date
Mar 15, 2021
Identifiers
DOI: 10.1007/s11102-021-01137-4
PMID: 33721175
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly. Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index. Seven patients (three male, four female) with a mean age of 48 ± 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly. Bifidobacterium, Collinsella, Bacteroides, Butyricimonas, Clostridium, Oscillospira, and Dialister were predominating in the control group. The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.

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