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The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation.

Authors
  • El Aidy, Sahar
  • Merrifield, Claire A
  • Derrien, Muriel
  • van Baarlen, Peter
  • Hooiveld, Guido
  • Levenez, Florence
  • Doré, Joel
  • Dekker, Jan
  • Holmes, Elaine
  • Claus, Sandrine P
  • Reijngoud, Dirk-Jan
  • Kleerebezem, Michiel
Type
Published Article
Journal
Gut
Publisher
BMJ
Publication Date
Sep 01, 2013
Volume
62
Issue
9
Pages
1306–1314
Identifiers
DOI: 10.1136/gutjnl-2011-301955
PMID: 22722618
Source
Medline
Keywords
License
Unknown

Abstract

This study elucidates the dynamic jejunal response to the microbiota and supports a prominent role for the jejunum in metabolic control, including glucose and energy homoeostasis. The molecular signatures of this process may help to find risk markers in the declining insulin sensitivity seen in human type 2 diabetes mellitus, for instance.

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