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Gut microbiome: a new player in gastrointestinal disease.

Authors
  • Gorkiewicz, Gregor1
  • Moschen, Alexander2
  • 1 Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010, Graz, Austria. [email protected] , (Austria)
  • 2 Christian Doppler Laboratory for Mucosal Immunology & Division of Internal Medicine I, Department of Medicine, Medical University Innsbruck, Peter-Mayr-Strasse 1, 6020, Innsbruck, Austria. , (Austria)
Type
Published Article
Journal
Virchows Archiv : an international journal of pathology
Publication Date
Jan 01, 2018
Volume
472
Issue
1
Pages
159–172
Identifiers
DOI: 10.1007/s00428-017-2277-x
PMID: 29243124
Source
Medline
Keywords
License
Unknown

Abstract

The gastrointestinal (GI) tract harbors a diverse and host-specific gut microbial community. Whereas host-microbe interactions are based on homeostasis and mutualism, the microbiome also contributes to disease development. In this review, we summarize recent findings connecting the GI microbiome with GI disease. Starting with a description of biochemical factors shaping microbial compositions in each gut segment along the longitudinal axis, improved histological techniques enabling high resolution visualization of the spatial microbiome structure are highlighted. Subsequently, inflammatory and neoplastic diseases of the esophagus, stomach, and small and large intestines are discussed and the respective changes in microbiome compositions summarized. Finally, approaches aiming to restore disturbed microbiome compositions thereby promoting health are discussed.

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