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Gut microbiome, metabolome and alopecia areata

Authors
  • Liu, Zhiyu1
  • Liu, Xiaoyan2
  • 1 School of Medicine of Zhejiang University, Hangzhou , (China)
  • 2 Department of Dermatology, The First Affiliated Hospital, School of Medicine of Zhejiang University, Hangzhou , (China)
Type
Published Article
Journal
Frontiers in Microbiology
Publisher
Frontiers Media SA
Publication Date
Nov 15, 2023
Volume
14
Identifiers
DOI: 10.3389/fmicb.2023.1281660
Source
Frontiers
Keywords
Disciplines
  • Microbiology
  • Review
License
Green

Abstract

Alopecia areata (AA) is a type of dermatological disease characterized by rapid and non-scarring hair loss of the scalp or body skin that may be related to genetic, immunological and physiological factors. It is now believed that AA is associated with oxidative stress, autoimmune disease, neuropsychological factors, pathogens, immune checkpoint inhibitors and microecological imbalance under the premise of host genetic susceptibility. In recent years, studies have revealed the significant role of the gut microbiome or metabolome in many aspects of human health. Diverse studies have revealed that the gut microbiome and metabolome have an important influence on skin conditions. This review highlights the relationship between AA and the gut microbiome or metabolome to provide novel directions for the prevention, clinical diagnosis and treatment of AA.

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