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Guillain-Barré syndrome: an ultrastructural study of peripheral nerve in 65 patients.

Authors
  • Brechenmacher, C
  • Vital, C
  • Deminiere, C
  • Laurentjoye, L
  • Castaing, Y
  • Gbikpi-Benissan, G
  • Cardinaud, J P
  • Favarel-Garrigues, J P
Type
Published Article
Journal
Clinical Neuropathology
Publisher
Dustri-Verlag Dr. Karl Feistle
Publication Date
Jan 01, 1987
Volume
6
Issue
1
Pages
19–24
Identifiers
PMID: 3552352
Source
Medline
License
Unknown

Abstract

65 biopsies of peripheral nerve from patients suffering from Guillain-Barré syndrome were studied by electron microscopy. In 48 cases there was macrophagic invasion of the Schwann cells of certain myelinated fibers, and in 32 of these cases some myelin sheaths were stripped away by an elongated macrophagic process. Vesicular disruption of the myelin sheath was observed in only 8 cases and in less than 1% of the myelinated fibers. Uncompacted myelin lamellae were observed in a few myelinated fibers. These ultrastructural lesions are analysed and commented on with a view to selecting patients who are to undergo plasma exchange.

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