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Guillain-Barré syndrome serum and anti-Campylobacter antibody do not exacerbate experimental autoimmune neuritis.

Authors
  • Hadden, R D
  • Gregson, N A
  • Gold, R
  • Willison, H J
  • Hughes, R A
Type
Published Article
Journal
Journal of Neuroimmunology
Publisher
Elsevier
Publication Date
Oct 01, 2001
Volume
119
Issue
2
Pages
306–316
Identifiers
PMID: 11585634
Source
Medline
License
Unknown

Abstract

To investigate whether antibodies are pathogenic in Guillain-Barré syndrome (GBS), we injected pre-treatment serum from 11 GBS patients intraperitoneally into rats in which the blood-nerve barrier had been opened by induction of mild adoptive transfer experimental autoimmune neuritis. There was no significant clinical, neurophysiological or pathological difference between rats receiving GBS serum compared with those receiving control serum, except that GBS serum caused minor excess weight loss. Murine monoclonal antibody to Campylobacter jejuni and gangliosides also did not exacerbate disease. This experiment failed to show antibody-mediated disease exacerbation and so does not support an antibody-mediated mechanism in GBS.

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