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Guided web-based treatment program for reducing cannabis use: a randomized controlled trial

  • Sinadinovic, Kristina1
  • Johansson, Magnus2, 3
  • Johansson, Ann-Sofie3
  • Lundqvist, Thomas4
  • Lindner, Philip1, 3, 5
  • Hermansson, Ulric1, 3
  • 1 Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden , Stockholm (Sweden)
  • 2 Karolinska Institutet, Stockholm, Sweden , Stockholm (Sweden)
  • 3 Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden , Stockholm (Sweden)
  • 4 Lund University, Lund, Sweden , Lund (Sweden)
  • 5 Stockholm University, Stockholm, Sweden , Stockholm (Sweden)
Published Article
Addiction Science & Clinical Practice
BioMed Central
Publication Date
Feb 18, 2020
DOI: 10.1186/s13722-020-00185-8
Springer Nature


BackgroundThe aim of this study was to investigate the effects of a web-based treatment program with therapist guidance for adults and adolescents with regular cannabis use from the general population.MethodsA double blinded randomized controlled trial with a parallel group design was conducted (intervention group n = 151, wait-list control group n = 152). Follow-up 12 weeks from treatment commencement of a 13-module intervention. The primary outcome was frequency of cannabis use. Time by group interaction effects were modeled using generalized estimated equations and the instrumental variable approach was used to estimate the effect of intervention adherence.ResultsAt follow-up, the intention to treat (ITT) analyses did not show any significant time by group effects. A significant association between intervention adherence and scores on the cannabis abuse screening test (CAST) was found. Secondary analysis excluding participants who had received other professional help revealed time by group effects for secondary outcomes gram cannabis consumed past week, number of dependency criteria and CAST score. Due to methodological limitations, these latter results should be interpreted with caution.ConclusionsIn this study we did not find a web-based treatment program with therapist guidance to be more effective than a waiting-list in reducing frequency of cannabis use.Trial registration The trial was pre-registered at (NCT02408640) April 3, 2015

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