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A guide to plasma membrane solute carrier proteins.

Authors
  • Pizzagalli, Mattia D1
  • Bensimon, Ariel1
  • Superti-Furga, Giulio1, 2
  • 1 CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. , (Austria)
  • 2 Center for Physiology and Pharmacology, Medical University of Vienna, Austria. , (Austria)
Type
Published Article
Journal
FEBS Journal
Publisher
Wiley (Blackwell Publishing)
Publication Date
May 01, 2021
Volume
288
Issue
9
Pages
2784–2835
Identifiers
DOI: 10.1111/febs.15531
PMID: 32810346
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 families that carry a wide variety of substances across cellular membranes. While members of this superfamily are found throughout cellular organelles, this review focuses on transporters expressed at the plasma membrane. At the cell surface, SLC proteins may be viewed as gatekeepers of the cellular milieu, dynamically responding to different metabolic states. With altered metabolism being one of the hallmarks of cancer, we also briefly review the roles that surface SLC proteins play in the development and progression of cancer through their influence on regulating metabolism and environmental conditions. © 2020 The CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

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