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Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!

Authors
  • Lima, Margarida
  • Pinto, Luísa
  • Dos Anjos Teixeira, Maria
  • Canelhas, Aurea
  • Mota, Alexandra
  • Cabeda, José Manuel
  • Silva, Cidália
  • Queirós, Maria Luís
  • Fonseca, Sónia
  • Santos, Ana Helena
  • Brochado, Paulo
  • Justiça, Benvindo
Type
Published Article
Journal
Cytometry. Part B, Clinical cytometry
Publication Date
Jan 01, 2003
Volume
51
Issue
1
Pages
41–44
Identifiers
PMID: 12500296
Source
Medline
License
Unknown

Abstract

We report a case of a patient with two B-cell lymphoproliferative disorders: CD5(-)/CD23(+) B-cell chronic lymphocytic leukemia and CD5(+)/CD23(-) mantle cell lymphoma. These disorders were diagnosed simultaneously based on flow cytometry, immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction-based molecular studies. The B-cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes.

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