Affordable Access

Guanidination of a peptide side chain amino group on a solid support.

Authors
Type
Published Article
Journal
International journal of peptide & protein research
0367-8377
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
37
Issue
5
Pages
425–429
Identifiers
PMID: 1917298
Source
Medline
License
Unknown

Abstract

A novel guanidination method of converting a peptide side chain amino group to a guanidino group on a solid support is described. Four guanidinating reagents were evaluated using a model tetrapeptide attached to a polystyrene resin. Experimental data indicate that the two nitroguanidinating reagents, but not the two tosylguanidinating reagents, can be used effectively in solid phase peptide synthesis.

Statistics

Seen <100 times