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Guanidination of a peptide side chain amino group on a solid support.

Authors
  • Tian, Z P
  • Roeske, R W
Type
Published Article
Journal
International journal of peptide & protein research
Publisher
Wiley (Blackwell Publishing)
Publication Date
May 01, 1991
Volume
37
Issue
5
Pages
425–429
Identifiers
PMID: 1917298
Source
Medline
License
Unknown

Abstract

A novel guanidination method of converting a peptide side chain amino group to a guanidino group on a solid support is described. Four guanidinating reagents were evaluated using a model tetrapeptide attached to a polystyrene resin. Experimental data indicate that the two nitroguanidinating reagents, but not the two tosylguanidinating reagents, can be used effectively in solid phase peptide synthesis.

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