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Growth of normal and malignant bone marrow cells.

Authors
  • Reizenstein, P
Type
Published Article
Journal
Leukemia Research
Publisher
Elsevier
Publication Date
Jan 01, 1990
Volume
14
Issue
8
Pages
679–681
Identifiers
PMID: 2201819
Source
Medline
License
Unknown

Abstract

Results of five different methods (heme breakdown, mitotic indices, total marrow cellularity and different methods of labelling indices) to determine bone marrow cell growth are reviewed. Normal immature erythroblasts and myeloblasts have generation times of about 5-10 h. Erythroblasts in neoplastic conditions (the myelodysplastic syndrome and polycythemia vera) have generation times which are significantly prolonged, by 12-75 per cent, but this may not be true for myeloblasts, since total labelling indices are increased (from normal 3.9 to 11.2 per cent) in the myelodysplastic syndrome. In contrast, generation times in aplastic anemia are significantly shortened, by about 70-80 per cent. Normal mature erythroblasts and promyelocytes have generation times of about 24 h, and the malignant prolongation may be even greater.

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