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Growth-mediated metabolic activation of promutagens in Aspergillus nidulans.

Authors
Type
Published Article
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
0027-5107
Publisher
Elsevier
Publication Date
Volume
80
Issue
2
Pages
265–272
Identifiers
PMID: 7010140
Source
Medline

Abstract

7 procarcinogens belonging to different chemical classes (nitrosamines, hydrazoalkanes, oxazaphosphorines and aromatic amines) were tested in A. nidulans for the induction of point mutations with two genetic systems (8-AG resistance and induction of methionine suppressors). Dimethylnitrosamine, diethylnitrosamine, nitrosomorpholine, dimethylhydrazine, procarbazine and cyclophosphamide gave positive results with a good dose--effect relationship in the growth-mediated assay, whereas they gave negative or borderline positive results in the plate incorporation assay. 2-Aminoanthracene was completely negative with both experimental procedures. DMN, DEN and NM were also tested for their ability to induce somatic segregation: all were positive when assayed in the growth-mediated assay.

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