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Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro.

Authors
  • Diegelmann, R F
  • Cohen, I K
  • McCoy, B J
Type
Published Article
Journal
Journal of Cellular Physiology
Publisher
Wiley
Publication Date
Feb 01, 1979
Volume
98
Issue
2
Pages
341–346
Identifiers
PMID: 422662
Source
Medline
License
Unknown

Abstract

Fibroblasts were isolated from keloid, normal skin, and normal scar and maintained in tissue culture for four passages. Growth kinetics were the same for all groups on days 2 through 12. However, the rate of collagen synthesis per fibroblast was greater in keloid derived cells than any controls at all growth phases. Keloid fibroblasts have an autonomous capacity to synthesize collagen at a significantly increased level in vitro, which may explain in part why these lesions are characterized by increased collagen deposition.

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