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Growth hormone in the regulation of hyperlipidemia.

Authors
  • Blackett, P R
  • Weech, P K
  • McConathy, W J
  • Fesmire, J D
Type
Published Article
Journal
Metabolism
Publisher
Elsevier
Publication Date
Feb 01, 1982
Volume
31
Issue
2
Pages
117–120
Identifiers
PMID: 6804746
Source
Medline
License
Unknown

Abstract

Plasma concentrations of triglyceride, cholesterol, and apolipoproteins A-I and B in young growth hormone deficient subjects were measured at intervals during the five weeks after initial hormone-replacement therapy. The mean concentrations of cholesterol, apolipoproteins A-I and B decreased significantly during that period: the decreases were progressive and in similar proportion to each other. Also, the amount by which apolipoprotein A-I concentration decreased was correlated with its plasmas concentration before treatment. The data suggests that growth hormone may play a role in the regulation of these three major plasma lipoprotein components and tend to suppress the development of hypercholesterolemia which has been observed in some adult growth hormone deficient subjects.

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