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[Growth of experimental neoplasms in mice with inhibition of endogenous prostaglandin synthesis].

Authors
Type
Published Article
Journal
Voprosy onkologii
Publication Date
Volume
40
Issue
7-12
Pages
323–327
Identifiers
PMID: 7610629
Source
Medline

Abstract

Prostaglandin inhibitor--indomethacin was found to significantly suppress the growth of 5 epithelial transplantable tumors in mice. Simultaneously, it stimulated the development of leukemias L-1210 and La and intraperitoneal melanoma B-16. It was also shown to stimulate the spontaneous development of leukemia in mice AKR. Its growth-inhibiting effect was in direct correlation with the rate of prostaglandin E2 synthesis in tumor. The data obtained point to a specific metabolism of polyunsaturated fatty acids in experimental tumors of varying histogenesis as well as the importance of prostaglandin E2 level for prognosis of the inhibitive effect of indomethacin.

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