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Growth differentiation factor 9 reverses activin A suppression of steroidogenic acute regulatory protein expression and progesterone production in human granulosa-lutein cells.

Authors
  • Shi, Feng-Tao
  • Cheung, Anthony P
  • Klausen, Christian
  • Huang, He-Feng
  • Leung, Peter C K
Type
Published Article
Journal
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Publication Date
Oct 01, 2010
Volume
95
Issue
10
Identifiers
DOI: 10.1210/jc.2010-0477
PMID: 20660033
Source
Medline
License
Unknown

Abstract

GDF9 attenuates the suppressive effects of activin A on StAR expression and progesterone production by increasing the expression of inhibin B, which acts as an activin A competitor.

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