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Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus.

Authors
  • Gräfe, U
  • Schade, W
  • Roth, M
  • Radics, L
  • Incze, M
  • Ujszászy, K
Type
Published Article
Journal
The Journal of antibiotics
Publication Date
Aug 01, 1984
Volume
37
Issue
8
Pages
836–846
Identifiers
PMID: 6434502
Source
Medline
License
Unknown

Abstract

Griseochelin, C33H60O7, isolated from an asporogenous strain of Streptomyces griseus represents a novel carboxylic acid antibiotic. The metabolite, which is active against Gram-positive bacteria, forms water-insoluble salts with mono- and divalent cations and binds alkaline-earth metal ions specifically in 2:1 (X2M) stoichiometry. Detailed spectral (IR, MS and NMR) studies provide full characterization of its constitution featuring a carboxylic acid function, a substituted tetrahydropyran ring, an allylic OH group which are accommodated within a tetrahydroxylated-octamethyl-C25 diene backbone.

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