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The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo

Authors
  • Trovò, L.1
  • Fuchs, C.2, 1
  • De Rosa, R.1
  • Barbiero, I.1
  • Tramarin, M.1
  • Ciani, E.2
  • Rusconi, L.1
  • Kilstrup-Nielsen, C.1
  • 1 Center of Neuroscience, Dept. Biotechnology and Life Sciences (DBSV), University of Insubria, Varese, Italy
  • 2 Dept. Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy
Type
Published Article
Journal
Neurobiology of Disease
Publisher
Elsevier
Publication Date
May 01, 2020
Volume
138
Identifiers
DOI: 10.1016/j.nbd.2020.104791
PMID: 32032735
PMCID: PMC7152796
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro; • Epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro; • DYRK1A levels and activity is increased in CDKL5 deficient neurons;

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