The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo

Authors

• Trovò, L.¹
• Fuchs, C.^{2, 1}
• De Rosa, R.¹
• Barbiero, I.¹
• Tramarin, M.¹
• Ciani, E.²
• Rusconi, L.¹
• Kilstrup-Nielsen, C.¹

• ¹ Center of Neuroscience, Dept. Biotechnology and Life Sciences (DBSV), University of Insubria, Varese, Italy
• ² Dept. Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy

Type

Published Article

Journal

Neurobiology of Disease

Publisher

Elsevier

Publication Date

May 01, 2020

Volume

138

Identifiers

DOI: 10.1016/j.nbd.2020.104791

PMID: 32032735

PMCID: PMC7152796

Source

PubMed Central

Keywords

• Ampa-R, α-Amino-3-Hydroxy-5-Methylisozasole-4-Propionic Acid Receptor
• Cdd, Cdkl5 Deficiency Disorder
• Cdkl5, Cyclin-Dependen Kinase-Like 5
• Div, Days In Vitro
• Ds, Down Syndrome
• Dyrk1A, Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase
• Egcg, Eipgallatocathechin-3-Gallate
• Gfp, Green Fluorescent Protein
• Ko, Knockout
• Pnd, Postnatal Day
• Psd95, Post-Synaptic Density Protein 95
• Wb, Western Blot
• Wt, Wild-Type

License

Unknown