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Green tea infusion alleviates neurodegeneration induced by mutant Huntingtin in Drosophila.

Authors
  • Varga, Júlia1, 2
  • Dér, Nikolett Petra1
  • Zsindely, Nóra1
  • Bodai, László1
  • 1 Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary. , (Hungary)
  • 2 Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary. , (Hungary)
Type
Published Article
Journal
Nutritional Neuroscience
Publisher
Maney Publishing
Publication Date
Mar 01, 2020
Volume
23
Issue
3
Pages
183–189
Identifiers
DOI: 10.1080/1028415X.2018.1484021
PMID: 29973113
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Objectives: Green tea infusion contains a complex mixture of polyphenolic compounds that were shown to provide health benefits. It was previously demonstrated that (-)-epigallocatechin-3-gallate, one of the major polyphenols present in green tea, has a suppressing effect on various aspects of pathogenesis in models of Huntington's disease (HD), an inherited neurodegenerative disorder. In this study, we aimed to investigate, whether green tea infusion prepared as for human consumption has similar positive effects.Methods: We used a transgenic Drosophila model of HD to study the effects of green tea on mutant Huntingtin induced phenotypes. We tested the effects of green tea infusion on mutant Huntingtin induced neurodegeneration, impaired motor performance, reduced viability and lifespan by pseudopupil assay, climbing assay, eclosion and survival tests, respectively. We used immunoblots to measure Huntingtin protein levels and tested generic health benefits of green tea by longevity analysis.Results: We found that green tea supplementation reduced mutant Huntingtin induced neurodegeneration in Drosophila and positively impacted the longevity of mutant Huntingtin expressing flies. However, green tea did not rescue reduced viability of Drosophila expressing mutant Huntingtin or increased longevity of wild-type fruit flies.Discussion: Our results indicate that green tea consumption might have a modest positive effect on symptoms of HD.

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