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Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia.

Authors
  • Whitwell, J L
  • Avula, R
  • Senjem, M L
  • Kantarci, K
  • Weigand, S D
  • Samikoglu, A
  • Edmonson, H A
  • Vemuri, P
  • Knopman, D S
  • Boeve, B F
  • Petersen, R C
  • Josephs, K A
  • Jack, C R Jr
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Apr 20, 2010
Volume
74
Issue
16
Pages
1279–1287
Identifiers
DOI: 10.1212/WNL.0b013e3181d9edde
PMID: 20404309
Source
Medline
License
Unknown

Abstract

The diffusivity of gray matter is increased in regions that are atrophic in frontotemporal dementia, suggesting disruption of the cytoarchitecture of remaining tissue. Furthermore, damage was identified in white matter tracts that interconnect these regions, supporting the hypothesis that these diseases involve different and specific brain networks.

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